Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

Abstract γ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After
nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins …

Microtubules are composed of α-tubulin and β-tubulin dimers positioned head-to-tail to form
protofilaments that associate laterally in varying numbers. It is not known how cellular …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …

The gamma-tubulin ring complex (γ-TuRC) is the principal microtubule nucleation template
in vertebrates. Recent cryo-EM reconstructions visualized the intricate quaternary structure …

The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and
dynamically changes its subcellular localization from the interphase nucleus to the …

Ran is a member of the Ras superfamily of proteins, which primarily regulates
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …

Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular
structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale …