Many standard and targeted therapies, as well as radiotherapy, have been shown to induce
an anti-tumour immune response, and immunotherapies rely on modulating the host …

Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

A knowledge of the historic and philosophical background gives that kind of independence
from prejudices of his generation from which most scientists are suffering. This …

Despite the availability of major histocompatibility complex (MHC)-binding peptide
prediction algorithms, the development of T-cell vaccines against pathogen and tumor …

What counts as an individual in the living world? What does it mean for a living thing to
remain the same through time, while constantly changing? These questions are the province …

Certain chemotherapeutic regimens trigger cancer cell death while inducing dendritic cell
maturation and subsequent immune responses. However, chemotherapy‐induced …

The self–non-self theory has dominated immunology since the 1950s. In the 1990s,
Matzinger and her colleagues suggested a new, competing theory, called the “danger …

Darwin described forces of selection acting upon individuals, but there remains a great deal
of controversy about the exact status and definition of a biological individual. Recently some …

Although current anticancer immunotherapies using immune checkpoint inhibitors (ICIs)
have been reported with a high clinical success rate, numerous patients still bear …

Immunology—though deeply experimental in everyday practice—is also a theoretical
discipline. Recent advances in the understanding of innate immunity, how it is triggered and …