BEIR VII develops the most up-to-date and comprehensive risk estimates for cancer and
other health effects from exposure to low-level ionizing radiation. It is among the first reports …

DNA damage responses (DDR) encompass DNA repair and signal transduction pathways
that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic
instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ …

We have proposed that an early step in tumor progression is the expression of a mutator
phenotype resulting from mutations in genes that normally function in the maintenance of …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Historical observations have suggested that endometrial carcinomas vary in histopathologic
appearance and clinical features. More recent, systematic studies have provided …

To investigate the role of the presumed DNA mismatch repair (MMR) gene Msh2 in genome
stability and tumorigenesis, we have generated cells and mice that are deficient for the …

Tumor-released DNA in blood represents a promising biomarker for cancer detection. It has
been postulated that tumor necrosis causes release of DNA of varying sizes, which contrasts …

The etiology of small cell lung cancer (SCLC) is strongly tied to cigarette smoking, and now
there is considerable information concerning molecular abnormalities involved in the …