Mechanisms of pathogenicity for the emerging fungus Candida auris

MV Horton, AM Holt, JE Nett - Plos Pathogens, 2023 - journals.plos.org
Candida auris recently emerged as an urgent public health threat, causing outbreaks of
invasive infections in healthcare settings throughout the world. This fungal pathogen persists …

The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

A common vesicle proteome drives fungal biofilm development

R Zarnowski, H Sanchez, A Jaromin… - Proceedings of the …, 2022 - National Acad Sciences
Extracellular vesicles mediate community interactions among cells ranging from unicellular
microbes to complex vertebrates. Extracellular vesicles of the fungal pathogen Candida …

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

H Brown Harding, GN Kwaku, CM Reardon… - Nature …, 2024 - nature.com
The host type I interferon (IFN) pathway is a major signature of inflammation induced by the
human fungal pathogen, Candida albicans. However, the molecular mechanism for …

Insight Into the Properties and Immunoregulatory Effect of Extracellular Vesicles Produced by Candida glabrata, Candida parapsilosis, and Candida tropicalis …

K Kulig, E Karnas, O Woznicka, P Kuleta… - Frontiers in cellular …, 2022 - frontiersin.org
Currently, non-albicans Candida species, including C. tropicalis, C. glabrata, and C.
parapsilosis, are becoming an increasing epidemiological threat, predominantly due to the …

Candida albicans hyphal extracellular vesicles are different from yeast ones, carrying an active proteasome complex and showing a different role in host immune …

R Martínez-López, ML Hernáez, E Redondo… - Microbiology …, 2022 - Am Soc Microbiol
Candida albicans is the principal causative agent of lethal fungal infections, predominantly
in immunocompromised hosts. Extracellular vesicles (EVs) have been described as crucial …

Inhibitory Effects of the Fungal Pigment Rubiginosin C on Hyphal and Biofilm Formation in Candida albicans and Candida auris

H Zeng, M Stadler, WR Abraham, M Müsken, H Schrey - Journal of Fungi, 2023 - mdpi.com
The two fungal human pathogens, Candida auris and Candida albicans, possess a variety
of virulence mechanisms. Among them are the formation of biofilms to protect yeast against …

Immunomodulatory potential of fungal extracellular vesicles: Insights for therapeutic applications

S Nenciarini, D Cavalieri - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicular organelles that perform a variety of
biological functions including cell communication across different biological kingdoms. EVs …

[HTML][HTML] Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi

K Kulig, M Rapala-Kozik, J Karkowska-Kuleta - Current Research in …, 2024 - Elsevier
Candida fungi exploit various virulence strategies to invade the human host, while host cells
employ diverse mechanisms to maintain homeostasis and respond to infection. Extracellular …

Candida auris Outbreaks: Current Status and Future Perspectives

S De Gaetano, A Midiri, G Mancuso, MG Avola… - Microorganisms, 2024 - mdpi.com
Candida auris has been identified by the World Health Organization (WHO) as a critical
priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream …