Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

There is an urgent need for new treatments for Chagas disease, a parasitic infection which
mostly impacts South and Central America. We previously reported on the discovery of …

Introduction Leishmaniasis is a neglected tropical infectious disease. The available limited
therapeutic options for leishmaniasis are inadequate due to their poor pharmacokinetic …

With over 200 million cases and close to half a million deaths each year, malaria is a threat
to global health, particularly in developing countries. Plasmodium falciparum, the parasite …

The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous
drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and …

Essential core pathways of cellular biology are preserved throughout evolution, highlighting
the importance of these pathways for both bacteria and human cancer cells alike. Cell …

We describe our discovery and development of potent and highly selective inhibitors of
human constitutive proteasome chymotryptic activity (β5c). Structure–activity relationship …

The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo
susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven …

The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various
cellular processes and present in all kingdoms of life. In mammals and yeast, p97 functions …