Voltage-gated sodium channel β subunits and their related diseases
AA Bouza, LL Isom - Voltage-Gated Sodium Channels: Structure, Function …, 2018 - Springer
Voltage-gated sodium channels are protein complexes comprised of one pore forming α
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …
Brugada syndrome: oligogenic or mendelian disease?
MM Monasky, E Micaglio, G Ciconte… - International Journal of …, 2020 - mdpi.com
Brugada syndrome (BrS) is diagnosed by a coved-type ST-segment elevation in the right
precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk …
precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk …
[HTML][HTML] Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy
AE Vendrov, H Xiao, A Lozhkin, T Hayami, G Hu… - Redox Biology, 2023 - Elsevier
In acute sympathetic stress, catecholamine overload can lead to stress cardiomyopathy. We
tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent …
tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent …
Voltage-gated sodium channel β subunits: the power outside the pore in brain development and disease
Voltage gated sodium channels (VGSCs) were first identified in terms of their role in the
upstroke of the action potential. The underlying proteins were later identified as saxitoxin …
upstroke of the action potential. The underlying proteins were later identified as saxitoxin …
[HTML][HTML] Mutations of voltage-gated ionic channels and risk of severe cardiac arrhythmias
A Dehghani-Samani… - Acta Cardiologica …, 2019 - ncbi.nlm.nih.gov
Background Arrhythmias as important malfunctions of heart are known as abnormal rhythm
of heart. Several causes can make arrhythmias and most of them are related to generation …
of heart. Several causes can make arrhythmias and most of them are related to generation …
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3
AI Moreno-Manuel, Á Macías, FM Cruz… - Cardiovascular …, 2024 - academic.oup.com
Aims Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-
of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2 …
of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2 …
Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models
F Fu, M Pietropaolo, L Cui, S Pandit, W Li… - PLoS …, 2022 - journals.plos.org
The mouse is a useful preclinical species for evaluating disease etiology due to the
availability of a wide variety of genetically modified strains and the ability to perform disease …
availability of a wide variety of genetically modified strains and the ability to perform disease …
Brugada syndrome
H Korlipara, G Korlipara, S Pentyala - Acta Cardiologica, 2021 - Taylor & Francis
Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome that causes a
heightened risk for ventricular tachyarrhythmias and sudden cardiac death. BrS is …
heightened risk for ventricular tachyarrhythmias and sudden cardiac death. BrS is …
Genomic analysis of circular RNAs in heart
Background Heart failure is a leading cause of human morbidity and mortality. Circular
RNAs (circRNAs) are a newly discovered class of RNA that have been found to have …
RNAs (circRNAs) are a newly discovered class of RNA that have been found to have …
Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal subunit regulation of the cardiac voltage-gated sodium channel
Voltage-gated sodium (Na V) channels drive the upstroke of the action potential and are
comprised of a pore-forming α-subunit and regulatory β-subunits. The β-subunits modulate …
comprised of a pore-forming α-subunit and regulatory β-subunits. The β-subunits modulate …