Voltage-gated sodium channels are protein complexes comprised of one pore forming α
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …

Brugada syndrome (BrS) is diagnosed by a coved-type ST-segment elevation in the right
precordial leads on the electrocardiogram (ECG), and it is associated with an increased risk …

In acute sympathetic stress, catecholamine overload can lead to stress cardiomyopathy. We
tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase 4)-dependent …

Voltage gated sodium channels (VGSCs) were first identified in terms of their role in the
upstroke of the action potential. The underlying proteins were later identified as saxitoxin …

Background Arrhythmias as important malfunctions of heart are known as abnormal rhythm
of heart. Several causes can make arrhythmias and most of them are related to generation …

Aims Short QT syndrome type 3 (SQTS3) is a rare arrhythmogenic disease caused by gain-
of-function mutations in KCNJ2, the gene coding the inward rectifier potassium channel Kir2 …

The mouse is a useful preclinical species for evaluating disease etiology due to the
availability of a wide variety of genetically modified strains and the ability to perform disease …

Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome that causes a
heightened risk for ventricular tachyarrhythmias and sudden cardiac death. BrS is …

Background Heart failure is a leading cause of human morbidity and mortality. Circular
RNAs (circRNAs) are a newly discovered class of RNA that have been found to have …

Voltage-gated sodium (Na V) channels drive the upstroke of the action potential and are
comprised of a pore-forming α-subunit and regulatory β-subunits. The β-subunits modulate …