Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

Background Most primary prostate cancers are multifocal with individual tumors harboring
different aggressiveness; however, the genomic heterogeneity among these tumors is poorly …

Tandem duplications (TDs) of the UBTF gene have been recently described as a recurrent
alteration in pediatric acute myeloid leukemia (AML). Here, by screening 1946 newly …

Background Gene fusions have been studied extensively, as frequent drivers of
tumorigenesis as well as potential therapeutic targets. In many well-known cases …

Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults
remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA …

Prostate cancer is a highly heterogeneous disease and typically multiple distinct cancer foci
are present at primary diagnosis. Molecular classification of prostate cancer can potentially …

Prostate cancer is unique among carcinomas in that a fusion gene created by a
chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG …

E26 transformation-specific (ETS) variant 4 (ETV4) is an important transcription factor that
belongs to the ETS transcription factor family and is essential for much cellular physiology …

Elucidating genetic aberrations in pediatric acute myeloid leukemia (AML) provides insight
in biology and may impact on risk-group stratification and clinical outcome. This study aimed …