A mosquito needs to ingest at least one male and one female gametocyte to become
infected with malaria. The sex of Plasmodium falciparum gametocytes can be determined …

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Sexually reproducing parasites, such as malaria parasites, experience a trade-off between
the allocation of resources to asexual replication and the production of sexual forms …

Malaria parasites exhibit a complex lifecycle, requiring extensive asexual replication in the
liver and blood of the vertebrate host, and in the haemocoel of the insect vector. Yet, they …

Mosquito transmission of the deadly malaria parasite Plasmodium falciparum is mediated by
mature sexual forms (gametocytes). Circulating in the vertebrate host, relatively few …

Malaria/HIV-1 co-infection has become a significant public health problem in the tropics
where there is geographical overlap of the two diseases. It is well described that co-infection …

While significant advances have been made in understanding Plasmodium falciparum
gametocyte biology and its relationship with malaria parasite transmission, the gametocyte …

Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes
per year. However, even in the same transmission area, the number of uncomplicated …

While significant advances have been made in the prevention and treatment of malaria in
recent years, these successes continue to fall short of the World Health Organization (WHO) …

Malaria parasites have coevolved with humans over thousands of years, mirroring their
migration out of Africa. They persist to this day, despite continuous elimination efforts …