Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease
MJ Dahl, A Kulesza, M Werkle-Bergner… - … & Biobehavioral Reviews, 2023 - Elsevier
Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …
However, aging leads to declining memory, disrupting older adult's lives. Memories are …
Is Alzheimer disease a disease?
AD Korczyn, LT Grinberg - Nature Reviews Neurology, 2024 - nature.com
Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …
implications. Extensive research has resulted in no cure for what is perceived as the most …
[HTML][HTML] The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
MJ Dahl, SL Bachman, S Dutt, S Düzel, NC Bodammer… - Nature Aging, 2023 - nature.com
Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …
decline. Recent research has also implicated noradrenaline in shaping late-life memory …
[HTML][HTML] Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau
M Van Egroo, JM Riphagen, NJ Ashton… - Molecular …, 2023 - nature.com
Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to
accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more …
accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more …
[HTML][HTML] Exploring the role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI studies and implications
Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …
[HTML][HTML] Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum
CP Lisgaras, HE Scharfman - Neurobiology of disease, 2023 - Elsevier
Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's
disease (AD) and preclinical models. The brain regions where IIS are largest are not known …
disease (AD) and preclinical models. The brain regions where IIS are largest are not known …
[HTML][HTML] Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status
The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest
sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's …
sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's …
Dietary tyrosine intake (FFQ) is associated with locus coeruleus, attention and grey matter maintenance: an MRI structural study on 398 healthy individuals of the …
Abstract Background and Objective It is documented that low protein and amino-acid dietary
intake is related to poorer cognitive health and increased risk of dementia. Degradation of …
intake is related to poorer cognitive health and increased risk of dementia. Degradation of …
[HTML][HTML] Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function
Background The locus coeruleus (LC) produces catecholamines (norepinephrine and
dopamine) and is implicated in a broad range of cognitive functions including attention and …
dopamine) and is implicated in a broad range of cognitive functions including attention and …
[HTML][HTML] Social activity mediates locus coeruleus tangle-related cognition in older adults
BS Zide, NJ Donovan, S Lee, S Nag, DA Bennett… - Molecular …, 2024 - nature.com
The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in
cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to …
cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to …