Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to
accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more …

Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's
disease (AD) and preclinical models. The brain regions where IIS are largest are not known …

The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest
sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's …

Abstract Background and Objective It is documented that low protein and amino-acid dietary
intake is related to poorer cognitive health and increased risk of dementia. Degradation of …

Background The locus coeruleus (LC) produces catecholamines (norepinephrine and
dopamine) and is implicated in a broad range of cognitive functions including attention and …

The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in
cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to …