Significance: Surgical microscopes provide adjustable magnification, bright illumination, and
clear visualization of the surgical field and have been increasingly used in operating rooms …

Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for
the characterization of small particles undergoing Brownian motion in randomly …

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of
deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw …

To date, brain imaging has largely relied on X-ray computed tomography and magnetic
resonance angiography, with their limited spatial resolution and long scanning times …

We introduce a dynamic speckle model (DSM) to simulate the temporal evolution of fully
developed speckle patterns arising from the interference of scattered light reemitted from …

Laser speckle is a complex interference phenomenon that can easily be understood, in
concept, but is difficult to predict mathematically, because it is a stochastic process. The use …

Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy
(SCOS) is a technique that has been recently developed to measure CBF, but the use of …

Laser speckle contrast imaging (LSCI) is a real-time full-field non-invasive technique, which
is broadly applied to visualize blood flow in biomedical applications. In its foundation is the …

Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are
critical to brain function, and dysregulated in neuropathologies such as brain tumors …

Although surgical and endovascular revascularization can be performed in peripheral
arterial disease (PAD), 40% of patients with critical limb ischemia do not have a …