Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …

Mitochondria are multifunctional organelles that not only produce energy for the cell, but are
also important for cell signalling, apoptosis and many biosynthetic pathways. In most cell …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) primarily affect the
motor and frontotemporal areas of the brain, respectively. These disorders share clinical …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of adult life, causing
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …

The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

Neurons are highly polarized cells with an elongated axon that extends far away from the
cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of …