Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

Neuromelanin-sensitive MRI is a burgeoning non-invasive neuroimaging method with an
increasing number of applications in psychiatric research. This MRI modality is sensitive to …

As an arousal hub region in the brain, the locus coeruleus (LC) has bidirectional
connections with the autonomic nervous system. Magnetic resonance imaging (MRI)-based …

Background: Increased exposure to ambient air pollution, especially fine particulate matter≤
2.5 μ m (PM 2.5) is associated with poorer brain health and increased risk for Alzheimer's …

The locus coeruleus (LC) is among the first brain structures impacted by Alzheimer's disease
(AD), and noradrenergic denervation may contribute to early neurovascular dysfunction in …

The locus coeruleus–norepinephrine system is thought to be involved in the clinical effects
of vagus nerve stimulation. This system is known to prevent seizure development and …

Objective: While there is a growing body of evidence indicating a relationship between
COPD and cognitive impairment, there is a gap in evidence regarding discussions of …

Chronic pain leads to tau accumulation and hippocampal atrophy in mice. In this study, we
provide one of the first assessments in humans, examining the associations of probable …

The pigment neuromelanin, produced in the locus coeruleus (LC) as a byproduct of
catecholamine synthesis, gives the “blue spot” its name, and both identifies LC neurons and …