Measuring biological age using omics data
J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
[HTML][HTML] Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
[HTML][HTML] Next-generation sequencing technology: current trends and advancements
H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …
research. NGS can sequence millions of DNA fragments at once, providing detailed …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …