The late 1990s were banner years in molecular neuroscience; seminal studies
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …

Regulated local translation—whereby specific mRNAs are transported and localized in
subcellular domains where they are translated in response to regional signals—allows for …

Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also
causes cognitive impairment, neurotoxicity and neurodevelopmental deficits. Yet, the …

Susceptibility or resilience to posttraumatic stress disorder (PTSD) depends on one's ability
to appropriately adjust synaptic plasticity for coping with the traumatic experience. Activity …

Temporal lobe epilepsy is the most common and refractory form of epilepsy in adults. Gene
expression within affected structures such as the hippocampus displays extensive …

Background Local translation at synapses is important for rapidly remodeling the synaptic
proteome to sustain long-term plasticity and memory. While the regulatory mechanisms …

Objective Posttranscriptional mechanisms are increasingly recognized as important
contributors to the formation of hyperexcitable networks in epilepsy. Messenger RNA …

Background This study aimed to characterize the clinical phenotype and genetic variations
in patients with Kallmann syndrome (KS). Methods This study involved the collection and …

The olfactory bulb (OB) has an extremely higher proportion of interneurons innervating
excitatory neurons than other brain regions, which is evolutionally conserved across …

The rodent olfactory bulb (OB) contains two distinct populations of postnatally born
interneurons, mainly granule cells (GCs), to support local circuits throughout life. During the …