Autoimmune diseases—connecting risk alleles with molecular traits of the immune system
M Gutierrez-Arcelus, SS Rich… - Nature Reviews …, 2016 - nature.com
Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
The transcription factor Myc is essential for the regulation of haematopoietic stem cells and
progenitors and has a critical function in haematopoietic malignancies. Here we show that …
progenitors and has a critical function in haematopoietic malignancies. Here we show that …
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …
longevity, yet the causes and functional consequences of these variants remain unclear. To …
Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos
MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …
exposures. Here, we characterized and controlled for this diversity in genome-wide …
[HTML][HTML] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
M Roederer, L Quaye, M Mangino, MH Beddall… - Cell, 2015 - cell.com
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
[HTML][HTML] Genetic variants regulating immune cell levels in health and disease
The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …
to defend against pathogens, but inadvertent immune system attacks on" self" result in …
Cytomegalovirus infection enhances the immune response to influenza
Cytomegalovirus (CMV) is a β-herpesvirus present in a latent form in most people
worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious …
worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious …
[HTML][HTML] Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
Background: Macronutrient intake varies substantially between individuals, and there is
evidence that this variation is partly accounted for by genetic variants. Objective: The …
evidence that this variation is partly accounted for by genetic variants. Objective: The …
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Determining whether potential causal variants for related diseases are shared can identify
overlapping etiologies of multifactorial disorders. Colocalization methods disentangle …
overlapping etiologies of multifactorial disorders. Colocalization methods disentangle …