The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are
sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard …

Members of the adenylate-forming family of enzymes play a role in the metabolism of
halogenated aromatics and of short, medium, and long chain fatty acids, as well as in the …

The development of versatile and sustainable catalytic strategies for amide bond formation
is a major objective for the pharmaceutical sector and the wider chemical industry. Herein …

Discovered in the 1920s, polyhydroxyalkanoates (PHA) are a naturally occurring class of
biopolyesters that have long been touted as a renewable, biodegradable plastic alternative …

Mycolic acids are indispensible lipids of Mycobacterium tuberculosis (Mtb), the causative
agent of tuberculosis (TB), and contribute to the distinctive architecture and impermeability of …

4-Chlorobenzoate: CoA ligase (CBL) belongs to the adenylate-forming family of enzymes
that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and …

Within the accompanying paper in this issue (Reger et al.(2008) Biochemistry, 47, 8016−
8025) we reported the X-ray structure of 4-chlorobenzoate: CoA ligase (CBL) bound with 4 …

The incorporation of nonacetate starter units during type II polyketide biosynthesis helps
diversify natural products. Currently, there are few enzymatic strategies for the incorporation …

The phenylacetic acid (PAA) degradation pathway is the sole aerobic route for phenylacetic
acid metabolism in bacteria and facilitates degradation of environmental pollutants such as …

Polyketides are chemically diverse and medicinally important biochemicals that are
biosynthesized from acyl-CoA precursors by polyketide synthases. One of the limitations to …