Sculpting with stem cells: how models of embryo development take shape

JV Veenvliet, PF Lenne, DA Turner, I Nachman… - …, 2021 - journals.biologists.com
During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton

R Fernandez-Gonzalez, M Peifer - Molecular Biology of the Cell, 2022 - Am Soc Cell Biol
Among the defining features of the animal kingdom is the ability of cells to change shape
and move. This underlies embryonic and postembryonic development, tissue homeostasis …

Cell cycle dynamics control fluidity of the developing mouse neuroepithelium

L Bocanegra-Moreno, A Singh, E Hannezo… - Nature Physics, 2023 - nature.com
As developing tissues grow in size and undergo morphogenetic changes, their material
properties may be altered. Such changes result from tension dynamics at cell contacts or …

Tension remodeling regulates topological transitions in epithelial tissues

F Pérez-Verdugo, S Banerjee - PRX Life, 2023 - APS
Cell neighbor exchanges play a critical role in regulating tissue fluidity during epithelial
morphogenesis and repair. In vivo, these neighbor exchanges are often hindered by the …

Robust statistical properties of T1 transitions in a multi-phase field model of cell monolayers

HP Jain, A Voigt, L Angheluta - Scientific Reports, 2023 - nature.com
Large-scale tissue deformation which is fundamental to tissue development hinges on local
cellular rearrangements, such as T1 transitions. In the realm of the multi-phase field model …

Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model

A Nestor-Bergmann, GB Blanchard… - PLoS computational …, 2022 - journals.plos.org
Cell intercalation is a key cell behaviour of morphogenesis and wound healing, where local
cell neighbour exchanges can cause dramatic tissue deformations such as body axis …

Active T1 transitions in cellular networks

C Duclut, J Paijmans, MM Inamdar, CD Modes… - The European Physical …, 2022 - Springer
In amorphous solids as in tissues, neighbor exchanges can relax local stresses and allow
the material to flow. In this paper, we use an anisotropic vertex model to study T1 …

Continuum theory for confluent cell monolayers: Interplay between cell growth, division, and intercalation

P Bandil, FJ Vernerey - Journal of the Mechanics and Physics of Solids, 2023 - Elsevier
Mechanical forces generated by dynamic cellular activities play a crucial role in the
morphogenesis and growth of biological tissues. While the influence of mechanics is clear …

Topologically-protected interior for three-dimensional confluent cellular collectives

T Zhang, JM Schwarz - Physical Review Research, 2022 - APS
Organoids are in vitro cellular collectives from which, for example, brain-like, or gut-like, or
kidney-like structures emerge. To make quantitative predictions regarding the morphology …

Controlled neighbor exchanges drive glassy behavior, intermittency, and cell streaming in epithelial tissues

A Das, S Sastry, D Bi - Physical Review X, 2021 - APS
Cell neighbor exchanges are integral to tissue rearrangements in biology, including
development and repair. Often, these processes occur via topological T1 transitions …