Comprehensive analysis of microRNA (miRNA) in cancer cells

N Kanwal, OR Al Samarrai, HMH Al-Zaidi… - Cellular, Molecular …, 2023 - cmbr-journal.com
MicroRNAs (miRNA) are a group of small non-coding RNAs that regulate gene expression
at the RNA level. MicroRNAs have positive regulatory effects on protein translation …

Drugs in clinical development to treat autosomal dominant polycystic kidney disease

T Bais, RT Gansevoort, E Meijer - Drugs, 2022 - Springer
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive
cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of …

The emerging role of MicroRNAs in bone diseases and their therapeutic potential

LA Bravo Vázquez, MY Moreno Becerril… - Molecules, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-
coding RNA molecules whose main function is the post-transcriptional regulation of gene …

A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease

H Ramalingam, S Kashyap, P Cobo-Stark, A Flaten… - Cell metabolism, 2021 - cell.com
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

R Lakhia, H Ramalingam, CM Chang… - Nature …, 2022 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD), among the most common human
genetic conditions and a frequent etiology of kidney failure, is primarily caused by …

Exploring the therapeutic significance of microRNAs and lncRNAs in kidney diseases

LA Bravo-Vázquez, S Paul, MG Colín-Jurado… - Genes, 2024 - mdpi.com
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of
transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA …

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

X Zhou, VE Torres - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

Recent findings on the role of microRNAs in genetic kidney diseases

H Askari, E Raeis-Abdollahi, MF Abazari… - Molecular biology …, 2022 - Springer
Background MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–
25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated …

Molecular genetics of renal ciliopathies

M Barroso-Gil, E Olinger, JA Sayer - Biochemical Society …, 2021 - portlandpress.com
Renal ciliopathies are a heterogenous group of inherited disorders leading to an array of
phenotypes that include cystic kidney disease and renal interstitial fibrosis leading to …

The role of N-methyladenosine modification in acute and chronic kidney diseases

S Qi, J Song, L Chen, H Weng - Molecular Medicine, 2023 - Springer
Abstract N 6-methyladenosine (m6A) modification is a kind of RNA modification in which
methylation occurs at the sixth N position in adenosine in RNA, which can occur in various …