Objective: Oxidative stress may be the unifying mechanism underlying the development of
comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress …

Purpose: Obesity may be a state of chronic oxidative stress. Oxidative stress may be the
mechanism underlying the development of co‐morbidities in obesity. This review provides a …

BACKGROUND: Treatment-resistant major depressive disorder (MDD) is a complex
condition, with very low remission rates. Physical exercise has been used, with some …

The effect of exercise on apoptosis in postmitotic tissues is not known. In this study, we
investigated the effect of regular moderate physical activity (ie, exercise training) on the …

Background Being overweight or obese is associated with an increased risk of
cardiovascular disease (CVD). Physical activity might reduce the risk associated with …

Myocardial ischemia–reperfusion (IR) injury is a major contributor to the morbidity and
mortality associated with coronary artery disease. Muscular exercise is a countermeasure to …

Stressful events may trigger disease processes in many different organ systems, with the
cardiovascular system being particularly vulnerable. Five-mo-old male rats had ad libitum …

Aging is characterized by a progressive decline in cardiac function. A critical contributor to
the age-related impairment in cardiac function is the loss of cardiac myocytes through …

Exercise leads to increases in circulating levels of peripheral blood mononuclear cells
(PBMCs) and to a simultaneous, seemingly paradoxical increase in both pro-and anti …

The objective of this work was to test the hypothesis that endurance training may be
protective against in vivo doxorubicin (DOX)-induced cardiomyopathy through mitochondria …