Diversity and evolution in the genome of Clostridium difficile

DR Knight, B Elliott, BJ Chang… - Clinical microbiology …, 2015 - Am Soc Microbiol
Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …

Capturing the environment of the Clostridioides difficile infection cycle

MK Schnizlein, VB Young - Nature Reviews Gastroenterology & …, 2022 - nature.com
Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

[HTML][HTML] Clostridium difficile infection in the community: a zoonotic disease?

MPM Hensgens, EC Keessen, MM Squire… - Clinical microbiology …, 2012 - Elsevier
Clostridium difficile infections (CDIs) are traditionally seen in elderly and hospitalized
patients who have used antibiotic therapy. In the community, CDIs requiring a visit to a …

Genome Analysis of Clostridium difficile PCR Ribotype 014 Lineage in Australian Pigs and Humans Reveals a Diverse Genetic Repertoire and Signatures of Long …

DR Knight, MM Squire, DA Collins… - Frontiers in microbiology, 2017 - frontiersin.org
Clostridium difficile PCR ribotype (RT) 014 is well-established in both human and porcine
populations in Australia, raising the possibility that C. difficile infection (CDI) may have a …

Virulence factors of Clostridium difficile and their role during infection

C Janoir - Anaerobe, 2016 - Elsevier
Clostridium difficile is the prominent etiological agent of healthcare-associated diarrhea. The
disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis …

Clostridium difficile Colonizes Alternative Nutrient Niches during Infection across Distinct Murine Gut Microbiomes

ML Jenior, JL Leslie, VB Young, PD Schloss - MSystems, 2017 - Am Soc Microbiol
Clostridium difficile is the largest single cause of hospital-acquired infection in the United
States. A major risk factor for Clostridium difficile infection (CDI) is prior exposure to …

Current application and future perspectives of molecular typing methods to study Clostridium difficile infections

CW Knetsch, TD Lawley, MP Hensgens… - …, 2013 - eurosurveillance.org
Molecular typing is an essential tool to monitor Clostridium difficile infections and outbreaks
within healthcare facilities. Molecular typing also plays a key role in defining the regional …

[HTML][HTML] Clostridium difficile in Dutch animals: their presence, characteristics and similarities with human isolates

MGJ Koene, D Mevius, JA Wagenaar… - Clinical Microbiology …, 2012 - Elsevier
The presence and characteristics of Clostridium difficile were investigated in 839 faecal
samples from seven different animal species in the Netherlands. The number of positive …

Clostridium difficile infection: evolution, phylogeny and molecular epidemiology

B Elliott, GO Androga, DR Knight, TV Riley - Infection, Genetics and …, 2017 - Elsevier
Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public
health threat. Despite growing attention, C. difficile remains a poorly understood pathogen …

Motility and Flagellar Glycosylation in Clostridium difficile

SM Twine, CW Reid, A Aubry, DR McMullin… - Journal of …, 2009 - Am Soc Microbiol
In this study, intact flagellin proteins were purified from strains of Clostridium difficile and
analyzed using quadrupole time of flight and linear ion trap mass spectrometers. Top-down …