Updates on managing type 2 diabetes mellitus with natural products: towards antidiabetic drug development

F Alam, MA Islam, MA Kamal… - Current medicinal …, 2018 - ingentaconnect.com
Over the years, natural products have shown success as antidiabetics in in vitro, in vivo
studies and clinical trials. Because natural product-derived drugs are more affordable and …

[PDF][PDF] Effect of a 12-week aquatic exercise on serum chemerin levels in men with type 2 diabetes

A Rafiei, AA Jazi, E Banitalebi - Iranian journal of rehabilitation research, 2018 - ijrn.ir
Introduction: Chemerin plays an important role in the glucose metabolism and inflammation.
It was shown that circulatory levels of chemerin increased in patients with type 2 diabetes …

Relationship between types and levels of free fatty acids, peripheral insulin resistance, and oxidative stress in T2DM: a case-control study

H Shiri, H Fallah, M Abolhassani, S Fooladi… - Plos one, 2024 - journals.plos.org
Free Fatty Acids (FFAs) are vital for energy homeostasis and the pathogenesis of a variety of
diseases, including diabetes. For the first time, we presumed and investigated the types and …

The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 …

MM Safhi, T Anwer, G Khan… - The Korean Journal …, 2018 - synapse.koreamed.org
The present study was carried out with the hypothesis that combination of canagliflozin and
omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac …

[HTML][HTML] Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies

NA Emad, Y Sultana, M Aqil, A Saleh, FA Nasr - Saudi Journal of …, 2023 - Elsevier
Pioglitazone (PGL) is an effective insulin sensitizer, however, side effects such as
accumulation of subcutaneous fat, edema, and weight gain as well as poor oral …

Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway

SM Eraky, NM Ramadan - The Journal of Nutritional Biochemistry, 2021 - Elsevier
Diabetic cardiomyopathy is a primary cause of increased morbidity and mortality in
diabetics. Evidence has suggested a pivotal role for interrupted mitochondrial dynamics and …

Synergistic effect of omega-3 fatty acids and oral-hypoglycemic drug on lipid normalization through modulation of hepatic gene expression in high fat diet with low …

S Khadke, P Mandave, A Kuvalekar, V Pandit… - Nutrients, 2020 - mdpi.com
Type 2 diabetes mellitus, which an outcome of impaired insulin action and its secretion, is
concomitantly associated with lipid abnormalities. The study was designed to evaluate the …

Elucidating fish oil-induced milk fat depression in dairy sheep: Milk somatic cell transcriptome analysis

A Suárez-Vega, PG Toral, B Gutiérrez-Gil, G Hervás… - Scientific Reports, 2017 - nature.com
In this study, RNA sequencing was used to obtain a comprehensive profile of the
transcriptomic changes occurring in the mammary gland of lactating sheep suffering from …

[PDF][PDF] Effect of fluoxetine on the pancreas of adult male albino rats and the possible protective role of omega-3: Light and electron microscopic study

S Youssef - International Journal of Clinical and Developmental …, 2017 - researchgate.net
Depression is linked with a high risk of type 2diabetes (T2D). The affiliation between
depression and diabetes might be correlated to depression itself and, or medications …

[HTML][HTML] Evaluation of osteopontin gene expression in endometrium of diabetic rat models treated with metformin and pioglitazone

ZS Hosseiny, P Nikpour, A Bakhtiary… - … Journal of Fertility & …, 2019 - ncbi.nlm.nih.gov
Background Osteopontin (Opn) is one of the co-factors involved in cell adhesion and
invasion during the implanta-tion process. Several reports have shown Opn expression …