Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In
immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet …

Background Despite advances in treatment options for thrombotic thrombocytopenic purpura
(TTP), there are still limited high quality data to inform clinicians regarding its appropriate …

Background Despite an increase in our understandings of pathogenesis of thrombotic
thrombocytopenic purpura (TTP), the approaches for initial diagnosis and management of …

A 27-year-old patient with a history of severe obstetrical complications and arterial
thrombosis received a diagnosis of hereditary thrombotic thrombocytopenic purpura (TTP) …

Ionizable cationic lipids are essential for efficient in vivo delivery of RNA by lipid
nanoparticles (LNPs). DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable …

Background Congenital thrombotic thrombocytopenic purpura (TTP) results from severe
hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and …

Hereditary Thrombotic Thrombocytopenic Purpura Hereditary thrombotic thrombocytopenic
purpura is an autosomal recessive disorder caused by the absence of a functional protease …

Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare thrombotic
microangiopathy characterized by severe congenital ADAMTS13 deficiency and recurring …

With timely and effective treatment, most patients with thrombotic thrombocytopenic purpura
(TTP) survive the acute TTP episode. In addition to the risk of relapse, TTP survivors have …