Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

The metameric pattern of somites is created based on oscillatory expression of clock genes
in presomitic mesoderm. However, the mechanism for converting the dynamic oscillation to …

The mechanisms underpinning the formation of patterned cellular landscapes has been the
subject of extensive study as a fundamental problem of developmental biology. In most …

Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

Secreted morphogen signals play a key role in the determination of cell fates during
embryonic development. BMP signaling is essential for mammalian gastrulation, as it …

During embryonic development, the timing of events at the cellular level must be
coordinated across multiple length scales to ensure the formation of a well-proportioned …

BMP signaling is essential for mammalian gastrulation, as it initiates a cascade of signals
that control self-organized patterning. As development is highly dynamic, it is crucial to …

During embryonic development, the timing of events at the cellular level must be
coordinated across multiple length scales to ensure the formation of a well-proportioned …

The study of pattern formation has benefited from our ability to reverse-engineer gene
regulatory network (GRN) structure from spatiotemporal quantitative gene expression data …