Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …

Circadian (~ 24 hour) clocks have a fundamental role in regulating daily physiology. The
transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Abstract Significance: Peroxiredoxins (Prxs) are thiol peroxidases with multiple functions in
the antioxidant defense and redox signaling network of the cell. Our progressing …

Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …

Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22‑27 kDa) non‑
seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides …

Like all aerobic organisms, plants and algae co-opt reactive oxygen species (ROS) as
signalling molecules to drive cellular responses to changes in their environment. In this …

The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …

The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …