Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Steroid hormones regulate diverse physiological functions such as reproduction, blood salt
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …

High Density Lipoproteins (HDLs) have long been considered as “good cholesterol,”
beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are …

Malignant tumors display remarkable heterogeneity to the extent that even at the same
tissue site different types of cells with varying genetic background may be found. In contrast …

Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be
toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess …

Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque
inflammation and necrosis. Bone marrow transplantation studies in ApoE-and LDLR …

During their metabolism, all lipoproteins undergo endocytosis, either to be degraded
intracellularly, for example in hepatocytes or macrophages, or to be re-secreted, for example …

HDL removes excess cholesterol from peripheral tissues and delivers it to the liver and
steroidogenic tissues via selective lipid uptake without catabolism of the HDL particle itself …

The association of unesterified fatty acid (FA) with the scavenger receptor CD36 has been
actively researched, with focuses on FA and oxidized low density lipoprotein (oxLDL) …

Drug delivery to malignant tumors is limited by several factors, including off-target toxicities
and suboptimal benefits to cancer patient. Major research efforts have been directed toward …