The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Tendon and ligament injury poses an increasingly large burden to society. This systematic
review explores whether mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) …

Standard cell culture guidelines often use media supplemented with antibiotics to prevent
cell contamination. However, relatively little is known about the effect of antibiotic use in cell …

Epigenomic regulation and lineage-specific gene expression act in concert to drive cellular
differentiation, but the temporal interplay between these processes is largely unknown …

Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by
phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate …

The human PXR (pregnane X receptor), a master regulator of drug metabolism, has
essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands …

Implantoplasty is a mechanical decontamination technique that consists of removing the
threads and polishing and smoothing the dental implant surface. During implantoplasty …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

Paralytic shellfish toxins (PSTs) are widely distributed neurotoxins, and the PST metabolic
detoxification mechanism in bivalves has received increasing attention. To reveal the effect …

It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing
nuclear receptor enriched in liver and intestine and is responsible for drug-drug interactions …