Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid
disease. We investigated 426 children and adolescents with primary myelodysplastic …

Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …

Nonimmune cells can have immunomodulatory roles that contribute to healthy development.
However, the molecular and cellular mechanisms underlying the immunomodulatory …

Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently
been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a …

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC)
generation is of particular importance for current hematopoietic regenerative approaches …

Abstract Background Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is
the cause of the COVID-19 pandemic and is the cause of increased mortality, especially …

Previous reports of GATA2 mutations have focused on the coding region of the gene or full
gene deletions. We recently identified 2 patients with novel insertion/deletion mutations …

Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths worldwide;
nearly half contain mutations in the receptor tyrosine kinase/RAS pathway. Here we show …