Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …

The yeast cell wall is a strong, but elastic, structure that is essential not only for the
maintenance of cell shape and integrity, but also for progression through the cell cycle …

It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell
from rapid changes in external osmotic potential. The wall is also critical for cell expansion …

The extensive diversity of membrane lipids is rarely appreciated by cell and molecular
biologists. Although most researchers are familiar with the three main classes of lipids in …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

A number of recent studies have provided new insights into the complexity of the endocytic
pathways originating at the plasma membrane of mammalian cells. Many of the molecules …

Clathrin-mediated endocytosis in the budding yeast Saccharomyces cerevisiae involves the
ordered recruitment, activity and disassembly of nearly 60 proteins at distinct sites on the …

Endocytosis functions to recycle plasma membrane components, to regulate cell-surface
expression of signalling receptors and to internalize nutrients in all eukaryotic cells …