The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

The development of general and selective methods to generate and transform reactive
intermediates such as radicals, cations, and anions remains an important objective in …

The combination of catalytic methods provides multiple advantages in organic synthesis,
allowing access to diverse organic molecules in a straightforward manner. Merging metal …

Steric hindrance modification-based pocket reshaping is an effective approach for enzyme–
substrate acceptance evolution. However, previous studies were limited to using the …

Co‐immobilization of enzymes and cofactors in a manner suitable for use in continuous flow
catalysis remains a great challenge because of the difficulty in ensuring the free accessibility …

Inspired by natural photosynthesis, photocatalytic NADH regeneration has drawn increasing
interest in the recent decade as it provides a perfect approach for NAD+ reduction into …

Thanks to advances in enzyme discovery and protein engineering combined with the
development of enzymatic multistep reaction cascades, new efficient routes for drug …

Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …