The horse reference genome from the Thoroughbred mare Twilight has been available for a
decade and, together with advances in genomics technologies, has led to unparalleled …

The functional annotation of livestock genomes is crucial for understanding the molecular
mechanisms that underpin complex traits of economic importance, adaptive evolution and …

The role of histone modifications in transcription remains incompletely understood. Here, we
examine the relationship between histone modifications and transcription using …

Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Recent advances in genomic sequencing technology and computational assembly methods
have allowed scientists to improve reference genome assemblies in terms of contiguity and …

Thoroughbred horses have been selected for racing performance for more than 400 years.
Despite continued selection, race times have not improved significantly during the past 60 …

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

Centromeres are epigenetically specified by the histone H3 variant CENP-A. Although
mammalian centromeres are typically associated with satellite DNA, we previously …

The domestication of the horse some 5,500 years ago followed those of dogs, sheep, goats,
cattle, and pigs by∼ 2,500–10,000 years. By providing fast transportation and transforming …