[HTML][HTML] Sites of chromosomal instability in the context of nuclear architecture and function
C Pentzold, M Kokal, S Pentzold, A Weise - Cellular and Molecular Life …, 2021 - Springer
Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin
that appear as breaks or gaps mostly tracing back to a loosened structure and not a real …
that appear as breaks or gaps mostly tracing back to a loosened structure and not a real …
[HTML][HTML] Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage
DNA repair requires reorganization of the local chromatin structure to facilitate access to and
repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin …
repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin …
A conserved histone H3-H4 interface regulates DNA damage tolerance and homologous recombination during the recovery from replication stress
M Hayashi, K Keyamura, A Yoshida… - … and cellular biology, 2021 - Am Soc Microbiol
In eukaryotes, genomic DNA is packaged into nucleosomes, which are the basal
components coordinating both the structures and functions of chromatin. In this study, we …
components coordinating both the structures and functions of chromatin. In this study, we …
Tolerance of DNA replication stress is promoted by fumarate through modulation of histone demethylation and enhancement of replicative intermediate processing in …
F Saatchi, AL Kirchmaier - Genetics, 2019 - academic.oup.com
Genome integrity is fundamental to viability and health and can be impacted by metabolic
alterations that affect chromatin composition. Saatchi and Kirchmaier present evidence that …
alterations that affect chromatin composition. Saatchi and Kirchmaier present evidence that …
Mechanisms of DNA Damage Response in Mammalian Oocytes
F Sun, P Sutovsky, AL Patterson… - … Mammalian Oocyte Quality …, 2024 - Springer
DNA damage poses a significant challenge to all eukaryotic cells, leading to mutagenesis,
genome instability and senescence. In somatic cells, the failure to repair damaged DNA can …
genome instability and senescence. In somatic cells, the failure to repair damaged DNA can …