Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …

Throughout their lives, humans encounter a plethora of substances capable of inducing
neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests …

The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory
effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon …

Background and Aim Hepatocellular carcinoma (HCC) is a type of cancer with high mortality
rates. The overexpression of microRNA-519d (miR-519d) has been explored in different …

Previously, macroautophagy/autophagy was demonstrated to be regulated inter alia by the
primary cilium. Mutations in RPGRIP1L cause ciliary dysfunctions resulting in severe human …

Gaucher's disease (GD) is an autosomal recessive disorder caused by mutations in the
GBA1 gene, which encodes acid β-glucocerebrosidase (GCase). Severe GBA1 mutations …

Autophagy is a highly regulated program of self-degradation of the cytosolic constituents that
has key roles during early development and in adult cell growth and homeostasis. To …

In mammals, the sense of hearing arises through a complex sequence of morphogenetic
events that drive the sculpting of the auditory sensory epithelium into its terminally functional …

Abstract c-FLIP (cellular FLICE-like inhibitory protein) protein is mostly known as an
apoptosis modulator. However, increasing data underline that c-FLIP plays multiple roles in …

Autophagy is a highly conserved catabolic process essential for embryonic development
and adult homeostasis. The autophagic machinery supplies energy by recycling intracellular …