Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated
with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate …

Mammalian poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear chromatin-
associated protein and belongs to a large family of enzymes that catalyzes the transfer of …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Poly (ADP-ribosylation), primarily via poly (ADP-ribose) polymerase-1 (PARP-1), is a
pluripotent cellular process important for maintenance of genomic integrity and RNA …

Although the molecular effectors of apoptotic cell death have been largely annotated over
the past 30 years, leading to a strong biological understanding of this process and its …

Background Sirtuins (Sirt), a family of nicotinamide adenine nucleotide (NAD) dependent
deacetylases, are implicated in energy metabolism and life span. Among the known Sirt …

Increased tau acetylation at K274 and K281 has been observed in the brains of Alzheimer's
disease (AD) patients and animal models, and mitochondrial dysfunction are noticeable and …