Higher accessibility and decreasing costs of next generation sequencing (NGS), availability
of commercial kits, and development of dedicated analysis pipelines, have allowed an …

Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …

Background The CASCADE trial showed that compared with usual care (UC), offering same-
day (SD) antiretroviral therapy (ART) during home-based human immunodeficiency virus …

Objectives WHO guidelines on ART define the HIV-1 viral load (VL) threshold for treatment
failure at 1000 copies/mL. The Switch Either near Suppression Or THOusand (SESOTHO) …

Drug resistance via drug-resistant mutations in the human immunodeficiency virus (HIV)
genome is the primary cause of antiviral therapy failure. Consequently, HIV drug resistance …

Background With the scale-up of antiretroviral therapy (ART), pre-treatment drug resistance
(PDR) appears≥ 10% amongst ART-initiators in many developing countries, including …

Background: There are an increasing number of articles focused on the prevalence and
clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing …

Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV.
However, the persistence of HIV-1 DNA as proviruses integrated into the human genome …

Background The high genetic diversity of HIV-1 has been shown to influence the global
distribution, disease progression, treatment success, and the development of an effective …

HIV-1 genotyping of larger pol-fragments from dried serum/plasma spots (DSS/DPS) is often
hindered by RNA-degradation during transportation at ambient temperature. We evaluated …