Purpose: To review information on performance characteristics for tests that are commonly
used to identify acute and chronic hepatic injury. Data Sources and Study Selection: A …

In polymer science today, much interest is focused on the controlled design of well-ordered
superstructures based on the self-assembly of carefully chosen building blocks. Of particular …

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …

Uridine‐diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes
that conjugate various endogenous and exogenous compounds with glucuronic acid and …

Increased concentrations of bilirubin glucuronides in blood plasma indicate hepatocellular
dysfunction. Elucidation of the transport processes of bilirubin conjugates across the …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Abstract The UDP‐glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for
detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid. For …

This article provides a comprehensive review on ascorbate metabolism in animal cells,
especially in hepatocytes. The authors deal with the synthesis and the breakdown of …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Bilirubin is the breakdown product of the haem moiety of haemoglobin and other
haemoproteins. Because of internal hydrogen bonding, bilirubin is water-insoluble and …