Microfluidic formulation of nanoparticles for biomedical applications

SJ Shepherd, D Issadore, MJ Mitchell - Biomaterials, 2021 - Elsevier
Nanomedicine has made significant advances in clinical applications since the late-20th
century, in part due to its distinct advantages in biocompatibility, potency, and novel …

Challenges and recent progress in oral drug delivery systems for biopharmaceuticals

B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines

SJ Shepherd, X Han, AJ Mukalel… - Proceedings of the …, 2023 - National Acad Sciences
Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …

Clogging of microfluidic systems

E Dressaire, A Sauret - Soft matter, 2017 - pubs.rsc.org
The transport of suspensions of microparticles in confined environments is associated with
complex phenomena at the interface of fluid mechanics and soft matter. Indeed, the …

Clogging transition of many-particle systems flowing through bottlenecks

I Zuriguel, DR Parisi, RC Hidalgo, C Lozano, A Janda… - Scientific reports, 2014 - nature.com
When a large set of discrete bodies passes through a bottleneck, the flow may become
intermittent due to the development of clogs that obstruct the constriction. Clogging is …

Synthesis of micro and nanostructures in microfluidic systems

S Marre, KF Jensen - Chemical Society Reviews, 2010 - pubs.rsc.org
In this critical review, we present an overview of the current progress in synthesis of micro
and nanostructures by using microfluidics techniques. Emphasis is placed on processes that …

[HTML][HTML] Designer emulsions using microfluidics

RK Shah, HC Shum, AC Rowat, D Lee, JJ Agresti… - Materials Today, 2008 - Elsevier
We describe new developments for the controlled fabrication of monodisperse emulsions
using microfluidics. We use glass capillary devices to generate single, double, and higher …

Nanoemulsions: the properties, methods of preparation and promising applications

MY Koroleva, EV Yurtov - Russian Chemical Reviews, 2012 - iopscience.iop.org
The properties of nanoemulsions and various methods for their preparation including the
high-energy and low-energy emulsification methods and the combined methods are …

Complex fluids and hydraulic fracturing

AC Barbati, J Desroches, A Robisson… - Annual review of …, 2016 - annualreviews.org
Nearly 70 years old, hydraulic fracturing is a core technique for stimulating hydrocarbon
production in a majority of oil and gas reservoirs. Complex fluids are implemented in nearly …

Managing solids in microreactors for the upstream continuous processing of fine chemicals

RL Hartman - Organic Process Research & Development, 2012 - ACS Publications
The management of solid compounds is a major challenge facing the upstream, continuous
processing of pharmaceuticals and fine chemicals. Many reactions relevant to fine chemical …