Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal
hematopoiesis-related somatic mutations and the development of myeloid malignancies …

The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

Defining the spatial architecture of hematopoiesis in the bone marrow is indispensable to
understand how this tissue ensures stepwise, balanced, differentiation to meet organism …

Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for
cancer patients. Dormant tumour cells can evade treatment and detection, while retaining …

Advances in biomaterial science have allowed for unprecedented insight into the ability of
material cues to influence stem cell function. These material approaches better recapitulate …