Clinical update on head and neck cancer: molecular biology and ongoing challenges
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
Drug repurposing from the perspective of pharmaceutical companies
Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …
patient populations. Numerous examples exist for the identification of new indications for …
NicheNet: modeling intercellular communication by linking ligands to target genes
Computational methods that model how gene expression of a cell is influenced by
interacting cells are lacking. We present NicheNet (https://github. com/saeyslab/nichenetr), a …
interacting cells are lacking. We present NicheNet (https://github. com/saeyslab/nichenetr), a …
The PRIDE database and related tools and resources in 2019: improving support for quantification data
Y Perez-Riverol, A Csordas, J Bai… - Nucleic acids …, 2019 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data, and is one …
the world's largest data repository of mass spectrometry-based proteomics data, and is one …
[HTML][HTML] An embryonic diapause-like adaptation with suppressed Myc activity enables tumor treatment persistence
E Dhimolea, R de Matos Simoes, D Kansara… - Cancer cell, 2021 - cell.com
Treatment-persistent residual tumors impede curative cancer therapy. To understand this
cancer cell state we generated models of treatment persistence that simulate the residual …
cancer cell state we generated models of treatment persistence that simulate the residual …
EPIC: a tool to estimate the proportions of different cell types from bulk gene expression data
Gene expression profiling is nowadays routinely performed on clinically relevant samples
(eg, from tumor specimens). Such measurements are often obtained from bulk samples …
(eg, from tumor specimens). Such measurements are often obtained from bulk samples …
ArrayExpress update–from bulk to single-cell expression data
Abstract ArrayExpress (https://www. ebi. ac. uk/arrayexpress) is an archive of functional
genomics data from a variety of technologies assaying functional modalities of a genome …
genomics data from a variety of technologies assaying functional modalities of a genome …
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …
how biological systems are regulated. However, fundamental aspects relating to which …
[HTML][HTML] The cellosaurus, a cell-line knowledge resource
A Bairoch - Journal of biomolecular techniques: JBT, 2018 - ncbi.nlm.nih.gov
The Cellosaurus is a knowledge resource on cell lines. It aims to describe all cell lines used
in biomedical research. Its scope encompasses both vertebrates and invertebrates …
in biomedical research. Its scope encompasses both vertebrates and invertebrates …
Distinct longevity mechanisms across and within species and their association with aging
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …