TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
Transient receptor potential channels in cardiac health and disease
T Hof, S Chaigne, A Récalde, L Salle, F Brette… - Nature Reviews …, 2019 - nature.com
Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel
M Lichtenegger, O Tiapko, B Svobodova… - Nature Chemical …, 2018 - nature.com
Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are
able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating …
able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating …
Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy
J Sabourin, A Boet, C Rucker-Martin, M Lambert… - Journal of molecular and …, 2018 - Elsevier
Background Right ventricular (RV) function is the most important prognostic factor for
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …
[HTML][HTML] Transient receptor potential channels and endothelial cell calcium signaling
The vascular endothelium is a broadly distributed and highly specialized organ. The
endothelium has a number of functions including the control of blood vessels diameter …
endothelium has a number of functions including the control of blood vessels diameter …
Pathophysiological Roles of the TRPV4 Channel in the Heart
S Chaigne, S Barbeau, T Ducret, R Guinamard… - Cells, 2023 - mdpi.com
The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …
Modulation and regulation of canonical transient receptor potential 3 (TRPC3) channels
BA Cole, EBE Becker - Cells, 2023 - mdpi.com
Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation
permeable channel that plays an essential role in calcium signalling. TRPC3 is highly …
permeable channel that plays an essential role in calcium signalling. TRPC3 is highly …
[HTML][HTML] The cardiac Na+-Ca2+ exchanger: from structure to function
M Ottolia, S John, A Hazan… - Comprehensive …, 2021 - ncbi.nlm.nih.gov
Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …