Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Ligand-based fluorine NMR screening has gained popularity in drug discovery projects
during the past decade and has become a powerful methodology to produce high quality …

G-quadruplexes are non-canonical secondary structures found in guanine rich regions of
DNA and RNA. Reports have indicated the wide occurrence of RNA G-quadruplexes across …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …

G‐quadruplexes (GQs) are four‐stranded secondary structures formed by G‐rich nucleic
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …

RNAs adopt diverse folded structures that are essential for function and thus play critical
roles in cellular biology. A striking example of this is the ribosome, a complex, three …

Since the characterization of mRNA in 1961, our understanding of the roles of RNA
molecules has significantly grown. Beyond serving as a link between DNA and proteins …

The G-quadruplexes form highly stable nucleic acid structures, which are implicated in
various biological processes in both DNA and RNA. Although DNA G-quadruplexes have …

Introduction The field of RNA-targeted small molecules is rapidly evolving, owing to the
advances in experimental and computational technologies. With the identification of several …