Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

Despite extensive genetic and neuroimaging studies, detailed cellular mechanisms
underlying schizophrenia and bipolar disorder remain poorly understood. Recent progress …

The power of human induced pluripotent stem cell (hiPSC)-based studies to resolve the
smaller effects of common variants within the size of cohorts that can be realistically …

We report locus-specific disintegration of megabase-scale chromosomal conformations in
brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine …

Neurodevelopmental disorders, including autism spectrum disorders, are highly male
biased, but the underpinnings of this are unknown. Striatal dysfunction has been strongly …

The development of human-induced pluripotent stem cells (hiPSCs) has made possible
patient-specific modeling across the spectrum of human disease. Here, we discuss recent …

NMDA receptors (NMDARs), a prominent subtype of glutamatergic receptors, are implicated
in the pathogenesis and development of neuropsychiatric disorders such as epilepsy …

The neuronal microtubule‐associated protein tau serves a critical role in regulating axonal
microtubule dynamics to support neuronal and synaptic functions. Furthermore, it contributes …

The watershed-hypothesis of schizophrenia asserts that over 200 different mutations
dysregulate distinct pathways that converge on an unspecified common mechanism (s) that …