[HTML][HTML] The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism

LA Ajram, AC Pereira, AMS Durieux, HE Velthius… - Progress in Neuro …, 2019 - Elsevier
Autism spectrum disorder (ASD) affects over 1: 100 of the population and costs the UK more
than£ 32bn and the USA more than $175 bn (£ 104bn) annually. Its core symptoms are …

Assessing metabolism and injury in acute human traumatic brain injury with magnetic resonance spectroscopy: current and future applications

MG Stovell, JL Yan, A Sleigh, MO Mada… - Frontiers in …, 2017 - frontiersin.org
Traumatic brain injury (TBI) triggers a series of complex pathophysiological processes.
These include abnormalities in brain energy metabolism; consequent to reduced tissue pO2 …

Big GABA: Edited MR spectroscopy at 24 research sites

M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix… - Neuroimage, 2017 - Elsevier
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …

Comparison of seven modelling algorithms for γ‐aminobutyric acid–edited proton magnetic resonance spectroscopy

AR Craven, PK Bhattacharyya, WT Clarke… - NMR in …, 2022 - Wiley Online Library
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the
human brain. Several algorithms are available for modelling these data, deriving metabolite …

Thalamic and prefrontal GABA concentrations but not GABAA receptor densities are altered in high-functioning adults with autism spectrum disorder

LK Fung, RE Flores, M Gu, KL Sun, D James… - Molecular …, 2021 - nature.com
The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in
autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating …

Test–retest reliability of the brain metabolites GABA and Glx with JPRESS, PRESS, and MEGA‐PRESS MRS sequences in vivo at 3T

A Baeshen, PO Wyss, A Henning… - Journal of Magnetic …, 2020 - Wiley Online Library
Background The optimization of magnetic resonance spectroscopy (MRS) sequences allows
improved diagnosis and prognosis of neurological and psychological disorders. Thus, to …

Validation of in vivo MRS measures of metabolite concentrations in the human brain

E Dhamala, I Abdelkefi, M Nguyen… - NMR in …, 2019 - Wiley Online Library
Purpose In vivo magnetic resonance spectroscopy (MRS) is the only technique capable of
non‐invasively assessing metabolite concentrations in the brain. The lack of alternative …

A comprehensive guide to MEGA-PRESS for GABA measurement

AL Peek, TJ Rebbeck, AM Leaver, SL Foster… - Analytical …, 2023 - Elsevier
The aim of this guideline is to provide a series of evidence-based recommendations that
allow those new to using MEGA-PRESS to produce high-quality data for the measurement of …

Quantifying GABA in addiction: a review of proton magnetic resonance spectroscopy studies

C Shyu, S Chavez, I Boileau, B Le Foll - Brain Sciences, 2022 - mdpi.com
Gamma-aminobutyric acid (GABA) signaling plays a crucial role in drug reward and the
development of addiction. Historically, GABA neurochemistry in humans has been difficult to …

The intra‐individual reliability of 1H‐MRS measurement in the anterior cingulate cortex across 1 year

MY Wang, M Korbmacher, R Eikeland… - Human Brain …, 2024 - Wiley Online Library
Magnetic resonance spectroscopy (MRS) is the primary method that can measure the levels
of metabolites in the brain in vivo. To achieve its potential in clinical usage, the reliability of …