Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …

Abdominal ultrasonography and intestinal ultrasonography are widely used as first
diagnostic tools for investigating patients with abdominal symptoms, mainly for excluding …

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal
peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause …

Objective. In the following review we outline how ultrasound can be used to measure
physiological processes in the gastrointestinal tract. Approach. We have investigated the …

Intestinal guanyl peptides like guanylin and uroguanylin are the potent regulators of fluid-ion
homeostasis. They are secreted from various cells of the intestinal mucosa, including …

Introduction Increased intestinal hydration by activation of the epithelial enzyme linked
receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation …

Introduction: Colorectal cancer remains the second leading cause of cancer death in the
United States, underscoring the need for novel therapies. Despite the successes of new …

Background With 25% prevalence of Crohn's disease, Familial GUCY2C diarrhea syndrome
(FGDS) is a monogenic disorder potentially suited to study initiating factors in inflammatory …

Chronic diarrhea presents a significant challenge for managing nutritional and electrolyte
deficiencies, especially in children, given the higher stakes of impacting growth and …

Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the
intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid …