Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Translating eco-evolutionary biology into therapy to tackle antibiotic resistance

F Sanz-García, T Gil-Gil, P Laborda, P Blanco… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy

M Boccella, B Santella, P Pagliano, A De Filippis… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent
years, among the multidrug-resistant microorganisms responsible for nosocomial infections …

Efflux in Gram-negative bacteria: what are the latest opportunities for drug discovery?

T Gil-Gil, P Laborda, LE Ochoa-Sánchez… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

[HTML][HTML] One health and global health view of antimicrobial susceptibility through the “eye” of Aeromonas: Systematic review and meta-analysis

DC Jones, EL LaMartina, JR Lewis, AJ Dahl… - International Journal of …, 2023 - Elsevier
Antimicrobial resistance (AMR) is one of the most pressing public health concerns; therefore,
it is imperative to advance our understanding of the factors influencing AMR from Global and …

Antibiotic Resistance in Pseudomonas

P Laborda, S Hernando-Amado, JL Martínez… - … and Control Strategies, 2022 - Springer
Pseudomonas is a bacterial genus, with a bona fide environmental habitat that comprises
different species, some of them causing diseases in humans and plants, as well as some …

The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Prevalence of ESKAPE bacteria in surface water and wastewater sources: Multidrug resistance and molecular characterization, an updated review

A Aguilar-Salazar, AV Martínez-Vázquez… - Water, 2023 - mdpi.com
ESKAPE bacteria represent a group of opportunistic bacterial pathogens that display
widespread antimicrobial resistance, including resistance to the last-line antibiotics, thereby …

Pseudomonadota in the oral cavity: a glimpse into the environment-human nexus

I Leão, TB De Carvalho, V Henriques… - Applied Microbiology …, 2023 - Springer
The phylum Pseudomonadota is amongst the most represented in the environment, with a
comparatively lower prevalence in the human oral cavity. The ubiquity of Pseudomonadota …

Evolution of habitat-dependent antibiotic resistance in Pseudomonas aeruginosa

P Laborda, JL Martínez… - Microbiology …, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen that usually causes difficult-
to-treat infections due to its low intrinsic antibiotic susceptibility and outstanding capacity for …