Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined
process occurring in seminiferous tubules of the testis. It is a temporal event whereby …

In all mammals, spermatogonia are defined as constituting the mitotic compartment of
spermatogenesis including stem, undifferentiated and differentiating cell types, possessing …

Continuity of cycling cell lineages relies on the activities of undifferentiated stem cell-
containing subpopulations. Transition to a differentiating state must occur periodically in a …

The long-term production of billions of spermatozoa relies on the regulated proliferation and
differentiation of spermatogonial stem cells (SSCs). To date only a few factors are known to …

In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate
to eventually become spermatozoa. This delicate balance must be maintained, as defects …

Spermatogenesis is the process by which spermatogonial stem cells divide and differentiate
into sperm. The role of growth factor receptors in regulating self-renewal and differentiation …

Background Spermatogenesis is an intricate developmental process during which
undifferentiated spermatogonia, containing spermatogonial stem cells (SSCs), undergo self …

Sertoli and germ cell interactions are essential for spermatogenesis and, thus, male fertility.
Sertoli cells provide a specialized microenvironment for spermatogonial stem cells to divide …

Ionizing radiation has been shown to arrest spermatogenesis despite the presence of
surviving stem spermatogonia, by blocking their differentiation. This block is a result of …

Gonocytes are primitive germ cells that reside in the seminiferous tubules of neonatal testes
and give rise to spermatogonia, thereby initiating spermatogenesis. Due to a lack of specific …