Lipid droplets: platforms with multiple functions in cancer hallmarks
ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
Polymer scaffolds as drug delivery systems
IR Calori, G Braga, PCC de Jesus, H Bi… - European Polymer …, 2020 - Elsevier
Drug delivery scaffolds are smart alternatives to conventional formulations and allow for
controlled spatiotemporal releases of active compounds. In several fields of human health …
controlled spatiotemporal releases of active compounds. In several fields of human health …
A brain cell atlas integrating single-cell transcriptomes across human brain regions
X Chen, Y Huang, L Huang, Z Huang, ZZ Hao, L Xu… - Nature Medicine, 2024 - nature.com
While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …
cell types and functions, studies including large numbers of donors and multiple brain …
Could 3D models of cancer enhance drug screening?
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
Nanomedicine for brain cancer
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
treatment approaches, with mortality rates staying practically unchanged over the past 30 …
Advances in engineering human tissue models
CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …
the investigation and understanding of specific biological events and processes under …
A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …
gliomas, and our understanding of drug transport across this critical biointerface remains …
[HTML][HTML] Extracellular matrix in glioblastoma: opportunities for emerging therapeutic approaches
E Mohiuddin, H Wakimoto - American journal of cancer research, 2021 - ncbi.nlm.nih.gov
Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …
microenvironment of normal tissues and malignancies such as the primary brain tumor …
Programmable DNA hydrogels as artificial extracellular matrix
The cell microenvironment plays a crucial role in regulating cell behavior and fate in
physiological and pathological processes. As the fundamental component of the cell …
physiological and pathological processes. As the fundamental component of the cell …
Nonlinear optical microscopy: From fundamentals to applications in live bioimaging
A recent challenge in the field of bioimaging is to image vital, thick, and complex tissues in
real time and in non-invasive mode. Among the different tools available for diagnostics …
real time and in non-invasive mode. Among the different tools available for diagnostics …