Lipid droplets: platforms with multiple functions in cancer hallmarks

ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Polymer scaffolds as drug delivery systems

IR Calori, G Braga, PCC de Jesus, H Bi… - European Polymer …, 2020 - Elsevier
Drug delivery scaffolds are smart alternatives to conventional formulations and allow for
controlled spatiotemporal releases of active compounds. In several fields of human health …

A brain cell atlas integrating single-cell transcriptomes across human brain regions

X Chen, Y Huang, L Huang, Z Huang, ZZ Hao, L Xu… - Nature Medicine, 2024 - nature.com
While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

Could 3D models of cancer enhance drug screening?

V Brancato, JM Oliveira, VM Correlo, RL Reis… - Biomaterials, 2020 - Elsevier
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …

Nanomedicine for brain cancer

S Quader, K Kataoka, H Cabral - Advanced Drug Delivery Reviews, 2022 - Elsevier
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

JP Straehla, C Hajal, HC Safford… - Proceedings of the …, 2022 - National Acad Sciences
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

[HTML][HTML] Extracellular matrix in glioblastoma: opportunities for emerging therapeutic approaches

E Mohiuddin, H Wakimoto - American journal of cancer research, 2021 - ncbi.nlm.nih.gov
Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …

Programmable DNA hydrogels as artificial extracellular matrix

Y Wei, K Wang, S Luo, F Li, X Zuo, C Fan, Q Li - Small, 2022 - Wiley Online Library
The cell microenvironment plays a crucial role in regulating cell behavior and fate in
physiological and pathological processes. As the fundamental component of the cell …

Nonlinear optical microscopy: From fundamentals to applications in live bioimaging

V Parodi, E Jacchetti, R Osellame, G Cerullo… - … in bioengineering and …, 2020 - frontiersin.org
A recent challenge in the field of bioimaging is to image vital, thick, and complex tissues in
real time and in non-invasive mode. Among the different tools available for diagnostics …