Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …

Reactive nitrogen species (RNS) are formed when there is an abnormal increase in the level
of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) and/or by the …

Renal ischemia-reperfusion (IR) contributes to the development of ischemic acute renal
failure (ARF). Multi-factorial processes are involved in the development and progression of …

Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA
leads to over-activation of poly (ADP-ribose) polymerase (PARP). PARP then generates the …

Here we overview the role of reactive nitrogen species (nitrosative stress) and associated
pathways in the pathogenesis of diabetic vascular complications. Increased extracellular …

Background: Since its discovery, poly (ADP-ribose) polymerase 1 (PARP-1) has been
extensively studied due to its regulatory role in numerous biologically crucial pathways …

Poly (ADP‐ribosyl) ation reactions, carried out by poly (ADP‐ribose) polymerases
(PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous …

Atherosclerosis is the leading cause of morbidity and mortality among Western populations.
Over the past two decades, considerable evidence has supported a crucial role for DNA …

The global burden of cardiovascular disease is increasing despite therapeutic advances in
medication and interventional technologies. Accumulated deoxyribonucleic acid (DNA) …