Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic
Abstract Over 30 years ago Professor David Barker first proposed the theory that events in
early life could explain an individual's risk of non‐communicable disease in later life: the …
early life could explain an individual's risk of non‐communicable disease in later life: the …
[HTML][HTML] GABA and glutamate in the preterm neonatal brain: in-vivo measurement by magnetic resonance spectroscopy
Cognitive and behavioral disabilities in preterm infants, even without obvious brain injury on
conventional neuroimaging, underscores a critical need to identify the subtle underlying …
conventional neuroimaging, underscores a critical need to identify the subtle underlying …
Cerebellar development after preterm birth
IY Iskusnykh, VV Chizhikov - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Preterm birth and its complications and the associated adverse factors, including brain
hemorrhage, inflammation, and the side effects of medical treatments, are the leading …
hemorrhage, inflammation, and the side effects of medical treatments, are the leading …
Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs
Background Children born preterm, especially boys, are at increased risk of developing
attention deficit hyperactivity disorder (ADHD) and learning difficulties. We propose that …
attention deficit hyperactivity disorder (ADHD) and learning difficulties. We propose that …
Reduced neurosteroid exposure following preterm birth and its' contribution to neurological impairment: a novel avenue for preventative therapies
Children born preterm are at an increased risk of developing cognitive problems and neuro-
behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety …
behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety …
Preterm birth alters the maturation of the GABAergic system in the human prefrontal cortex
H Lacaille, CM Vacher, AA Penn - Frontiers in Molecular …, 2022 - frontiersin.org
Developmental changes in GABAergic and glutamatergic systems during frontal lobe
development have been hypothesized to play a key role in neurodevelopmental disorders …
development have been hypothesized to play a key role in neurodevelopmental disorders …
Age and sex influences gamma-aminobutyric acid concentrations in the developing brain of very premature infants
Gamma-aminobutyric acid (GABA) and glutamate are principal neurotransmitters essential
for late gestational brain development and may play an important role in prematurity-related …
for late gestational brain development and may play an important role in prematurity-related …
GABAA receptors expressed in oligodendrocytes cultured from the neonatal rat contain α3 and γ1 subunits and present differential functional and pharmacological …
Oligodendrocytes (OLs) express functional GABAA receptors (GABAARs) that are activated
by GABA released at synaptic contacts with axons or by ambient GABA in extrasynaptic …
by GABA released at synaptic contacts with axons or by ambient GABA in extrasynaptic …
Perinatal compromise contributes to programming of GABAergic and glutamatergic systems leading to long‐term effects on offspring behaviour
Extensive evidence now shows that adversity during the perinatal period is a significant risk
factor for the development of neurodevelopmental disorders long after the causative event …
factor for the development of neurodevelopmental disorders long after the causative event …
Sedation and anesthesia for imaging of the infant and neonate—a brief review
FP Beaulieu, G Zuckerberg, K Coletti, E Mapelli… - Pediatric …, 2024 - Springer
Sedation and anesthesia are often required in order to facilitate collection of high-quality
imaging studies free of significant motion artifact for infants and neonates. Provision of safe …
imaging studies free of significant motion artifact for infants and neonates. Provision of safe …