Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Innate immune evasion strategies of SARS-CoV-2

JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5

H Shuai, JFW Chan, B Hu, Y Chai, C Yoon, H Liu… - …, 2023 - thelancet.com
Summary Background Among the Omicron sublineages that have emerged, BA. 1, BA. 2,
BA. 5, and their related sublineages have resulted in the largest number of infections. While …

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2

B Hu, JFW Chan, H Liu, Y Liu, Y Chai… - Emerging microbes & …, 2022 - Taylor & Francis
ABSTRACT SARS-CoV-2 B. 1.1. 529.1 (Omicron BA. 1) emerged in November 2021 and
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …

The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J Xie, W Li, L Su, G Zhang, J Xu… - Signal transduction and …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …

Altered host protease determinants for SARS-CoV-2 Omicron

JFW Chan, X Huang, B Hu, Y Chai, H Shi, T Zhu… - Science …, 2023 - science.org
Successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
requires proteolytic cleavage of the viral spike protein. While the role of the host …

Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target

J Shi, T Du, J Wang, C Tang, M Lei, W Yu, Y Yang… - Science …, 2023 - science.org
The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …

[HTML][HTML] A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

JFW Chan, YJ Oh, S Yuan, H Chu, ML Yeung… - Cell Reports …, 2022 - cell.com
Summary" Pan-coronavirus" antivirals targeting conserved viral components can be
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …

Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response

X Wang, TTT Yuen, Y Dou, J Hu, R Li, Z Zeng… - Nature …, 2023 - nature.com
The overall success of worldwide mass vaccination in limiting the negative effect of the
COVID-19 pandemics is inevitable, however, recent SARS-CoV-2 variants of concern …

Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA. 2/5 subvariants in the upper and lower respiratory tract

B Hu, JFW Chan, Y Liu, H Liu, YX Chen, H Shuai… - …, 2024 - thelancet.com
Summary Background Earlier Omicron subvariants including BA. 1, BA. 2, and BA. 5
emerged in waves, with a subvariant replacing the previous one every few months. More …