Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …

Mitochondria have been increasingly recognized as the important players in the aging
process. Most aging-related diseases, particularly, neurodegenerative diseases, have …

Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that
convey communication from adipose tissue to other organs. Here, to delineate their role as …

Background Mitochondria play an important role in cellular metabolism, and their
dysfunction is postulated to be involved in metabolic disturbances. Mitochondrial DNA is …

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

Background Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and
mortality. Little is known about the factors that contribute to the chronic inflammatory state …

Pancreatic β‑cells are the only source of insulin in humans. Mitochondria uses pyruvate to
produce ATP as an intermediate link between glucose intake and insulin secretion in β‑cells …

Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular
mechanisms have emerged supporting its biological effects but with little information …

Developing novel drugs/targets remains a major effort toward controlling obesity-related
type 2 diabetes (diabesity). Melatonin controls obesity and improves glucose homeostasis in …